| EC |
2.7.1.95 |
| Accepted name: |
kanamycin kinase |
| Reaction: |
ATP + kanamycin = ADP + kanamycin 3′-phosphate |
| Glossary: |
kanamycin |
| Other name(s): |
neomycin-kanamycin phosphotransferase; |
| Systematic name: |
ATP:kanamycin 3′-O-phosphotransferase |
| Comments: |
Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 62213-36-9 |
| References: |
| 1. |
Doi, O., Ogura, M., Tanaka, N. and Umezawa, H. Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginosa. Appl. Microbiol. 16 (1968) 1276–1281. [PMID: 4970990] |
| 2. |
Dolin, M.I. The Streptococcus faecalis oxidases for reduced diphosphopyridine nucleotide. III. Isolation and properties of a flavin peroxidase for reduced diphosphopyridine nucleotide. J. Biol. Chem. 225 (1957) 557–573. [PMID: 13416259] |
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| [EC 2.7.1.95 created 1976] |
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