The Enzyme Database

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EC 2.7.1.52     
Accepted name: fucokinase
Reaction: ATP + L-fucose = ADP + β-L-fucose 1-phosphate
For diagram of GDP-L-fucose and GDP-mannose biosynthesis, click here
Other name(s): fucokinase (phosphorylating); fucose kinase; L-fucose kinase; L-fucokinase; ATP:6-deoxy-L-galactose 1-phosphotransferase; ATP:L-fucose 1-phosphotransferase
Systematic name: ATP:β-L-fucose 1-phosphotransferase
Comments: Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37278-00-5
References:
1.  Ishihara, H., Massaro, D.J. and Heath, E.C. The metabolism of L-fucose. 3. The enzymatic synthesis of β-L-fucose 1-phosphate. J. Biol. Chem. 243 (1968) 1103–1109. [PMID: 5646161]
2.  Butler, W. and Serif, G.S. Fucokinase, its anomeric specificity and mechanism of phosphate group transfer. Biochim. Biophys. Acta 829 (1985) 238–243. [PMID: 2986701]
3.  Park, S.H., Pastuszak, I., Drake, R. and Elbein, A.D. Purification to apparent homogeneity and properties of pig kidney L-fucose kinase. J. Biol. Chem. 273 (1998) 5685–5691. [PMID: 9488699]
[EC 2.7.1.52 created 1972, modified 2004]
 
 


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