The Enzyme Database

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EC 2.7.1.36     
Accepted name: mevalonate kinase
Reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
For diagram of terpenoid biosynthesis, click here
Other name(s): mevalonate kinase (phosphorylating); mevalonate phosphokinase; mevalonic acid kinase; mevalonic kinase; mevalonate 5-phosphotransferase ; MVA kinase; ATP:mevalonate 5-phosphotransferase
Systematic name: ATP:(R)-mevalonate 5-phosphotransferase
Comments: CTP, GTP and UTP can also act as donors.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9026-52-2
References:
1.  Hellig, H. and Popják, G. Studies on the biosynthesis of cholesterol. XIII. Phosphomevalonic kinase from liver. J. Lipid Res. 2 (1961) 235–243.
2.  Levy, G.B. and Popják, G. Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver. Biochem. J. 75 (1960) 417–428. [PMID: 14416398]
3.  Markley, K. and Smallman, E. Mevalonic kinase in rabbit liver. Biochim. Biophys. Acta 47 (1961) 327–335.
4.  Tchen, T.T. Mevalonic kinase: purification and properties. J. Biol. Chem. 233 (1958) 1100–1103. [PMID: 13598740]
[EC 2.7.1.36 created 1961]
 
 


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