The Enzyme Database

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Accepted name: leucine transaminase
Reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
For diagram of reaction, click here, for diagram of leucine biosynthesis, click here and for diagram of mechanism, click here
Other name(s): L-leucine aminotransferase; leucine 2-oxoglutarate transaminase; leucine aminotransferase; leucine-α-ketoglutarate transaminase
Systematic name: L-leucine:2-oxoglutarate aminotransferase
Comments: A pyridoxal-phosphate protein. This enzyme differs from EC, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9030-37-9
1.  Aki, K., Ogawa, K. and Ichihara, A. Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver. Biochim. Biophys. Acta 159 (1968) 276–284. [PMID: 4968655]
2.  Ikeda, T., Konishi, Y. and Ichihara, A. Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of rat liver mitochondria. Biochim. Biophys. Acta 445 (1976) 622–631. [PMID: 974100]
[EC created 1961, modified 1982]

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