The Enzyme Database

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EC 2.6.1.26     
Accepted name: thyroid-hormone transaminase
Reaction: L-3,5,3′-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
For diagram of reaction, click here and for mechanism, click here
Other name(s): 3,5-dinitrotyrosine transaminase; thyroid hormone aminotransferase
Systematic name: L-3,5,3′-triiodothyronine:2-oxoglutarate aminotransferase
Comments: A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC 2.6.1.24 diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 51004-29-6
References:
1.  Soffer, R.L., Hechtman, P. and Savage, M. L-Triiodothyronine aminotransferase. J. Biol. Chem. 248 (1973) 1224–1230. [PMID: 4686924]
[EC 2.6.1.26 created 1972]
 
 


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