The Enzyme Database

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EC 2.5.1.99     
Accepted name: all-trans-phytoene synthase
Reaction: 2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate (overall reaction)
(1a) 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate
(1b) prephytoene diphosphate = all-trans-phytoene + diphosphate
For diagram of squalene, phytoene and 4,4′-diapophytoene biosynthesis, click here
Other name(s): prephytoene-diphosphate synthase (ambiguous); phytoene synthetase (ambiguous); PSase (ambiguous); geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous); 15-trans-phytoene synthase
Systematic name: geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase (all-trans-phytoene forming)
Comments: Requires Mn2+ for activity. The enzyme from the bacterium Pantoea agglomerans (previously known as Erwinia herbicola) produces the all-trans isomer of phytoene. cf. EC 2.5.1.32, 15-cis-phytoene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Gregonis, D.E. and Rilling, H.C. The stereochemistry of trans-phytoene synthesis. Some observations on lycopersene as a carotene precursor and a mechanism for the synthesis of cis- and trans-phytoene. Biochemistry 13 (1974) 1538–1542. [PMID: 4819767]
2.  Iwata-Reuyl, D., Math, S.K., Desai, S.B. and Poulter, C.D. Bacterial phytoene synthase: molecular cloning, expression, and characterization of Erwinia herbicola phytoene synthase. Biochemistry 42 (2003) 3359–3365. [PMID: 12641468]
[EC 2.5.1.99 created 2012]
 
 


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