The Enzyme Database

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Accepted name: uracilylalanine synthase
Reaction: O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate
For diagram of O3-Acetyl-L-serine metabolism, click here
Glossary: O-acetyl-L-serine = (2S)-3-acetyloxy-2-aminopropanoic acid
3-(uracil-1-yl)-L-alanine = L-willardiine
3-(uracil-3-yl)-L-alanine = L-isowillardiine
Other name(s): O3-acetyl-L-serine acetate-lyase (adding uracil); isowillardiine synthase; willardiine synthase; 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase; O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase
Systematic name: O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase
Comments: The enzyme produces the non-proteinogenic amino acid L-willardiine, which is naturally found in the plants Acacia willardiana, Mimosa pigra, and Pisum sativum (pea). The enzyme from Pisum species also produces L-isowillardiine. Not identical with EC cysteine synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 113573-73-2
1.  Ahmmad, M.A.S., Maskall, C.S. and Brown, E.G. Partial-purification and properties of willardiine and synthase activity from Pisum sativum. Phytochemistry 23 (1984) 265–270.
2.  Ikegami, F., Kaneko, M., Lambein, F., Kuo, Y.-H. and Murakoshi, I. Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum. Phytochemistry 26 (1987) 2699–2704.
3.  Murakoshi, I., Ikegami, F., Ookawa, N., Ariki, T., Haginiwa, J., Kuo, Y.-H. and Lambein, F. Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants. Phytochemistry 17 (1978) 1571–1576.
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