The Enzyme Database

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EC 2.4.2.3     
Accepted name: uridine phosphorylase
Reaction: uridine + phosphate = uracil + α-D-ribose 1-phosphate
Other name(s): pyrimidine phosphorylase; UrdPase; UPH; UPase
Systematic name: uridine:phosphate α-D-ribosyltransferase
Comments: The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. The mammalian enzyme also accepts 2′-deoxyuridine.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9030-22-2
References:
1.  Canellakis, E.S. Pyrimidine metabolism. II. Enzymatic pathways of uracil anabolism. J. Biol. Chem. 227 (1957) 329–338. [PMID: 13449076]
2.  Paege, L.M. and Schlenk, F. Bacterial uracil riboside phosphorylase. Arch. Biochem. Biophys. 40 (1952) 42–49. [PMID: 12997187]
3.  Leer, J.C., Hammer-Jespersen, K. and Schwartz, M. Uridine phosphorylase from Escherichia coli. Physical and chemical characterization. Eur. J. Biochem. 75 (1977) 217–224. [PMID: 16751]
4.  Pontis, H., Degerstedt, G. and Reichard, P. Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor. Biochim. Biophys. Acta 51 (1961) 138–147. [PMID: 13737038]
5.  Watanabe, S. and Uchida, T. Cloning and expression of human uridine phosphorylase. Biochem. Biophys. Res. Commun. 216 (1995) 265–272. [PMID: 7488099]
6.  Liu, M., Cao, D., Russell, R., Handschumacher, R.E. and Pizzorno, G. Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors. Cancer Res. 58 (1998) 5418–5424. [PMID: 9850074]
[EC 2.4.2.3 created 1961]
 
 


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