ExplorEnz: EC 2.4.1.41

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2.4.1.41

Accepted name:

polypeptide N-acetylgalactosaminyltransferase

Reaction:

UDP-N-acetyl-α-D-galactosamine + polypeptide = UDP + N-acetyl-α-D-galactosaminyl-polypeptide

Other name(s):

protein-UDP acetylgalactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase; UDP-N-acetylgalactosamine:κ-casein polypeptide N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; glycoprotein acetylgalactosaminyltransferase; polypeptide-N-acetylgalactosamine transferase; UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase; ppGalNAc-T

Systematic name:

UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase

Comments:

Requires both Mn²⁺ and Ca²⁺. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, κ-casein, apofetuin and some other acceptors of high molecular mass.

Links to other databases:

BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 9075-15-4

References:

1.	Sugiura, M., Kawasaki, T. and Yamashina, I. Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66. J. Biol. Chem. 257 (1982) 9501–9507. [PMID: 6809738]
2.	Takeuchi, M., Yoshikawa, M., Sasaki, R. and Chiba, H. Purification and characterization of UDP-N-acetylgalactosamine-κ-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow. Agric. Biol. Chem. 49 (1985) 1059–1069.

[EC 2.4.1.41 created 1972, modified 1989]