The Enzyme Database

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EC 2.4.1.41     
Accepted name: polypeptide N-acetylgalactosaminyltransferase
Reaction: UDP-N-acetyl-α-D-galactosamine + polypeptide = UDP + N-acetyl-α-D-galactosaminyl-polypeptide
Other name(s): protein-UDP acetylgalactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase; UDP-N-acetylgalactosamine:κ-casein polypeptide N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; glycoprotein acetylgalactosaminyltransferase; polypeptide-N-acetylgalactosamine transferase; UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase; ppGalNAc-T
Systematic name: UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase
Comments: Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, κ-casein, apofetuin and some other acceptors of high molecular mass.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9075-15-4
References:
1.  Sugiura, M., Kawasaki, T. and Yamashina, I. Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66. J. Biol. Chem. 257 (1982) 9501–9507. [PMID: 6809738]
2.  Takeuchi, M., Yoshikawa, M., Sasaki, R. and Chiba, H. Purification and characterization of UDP-N-acetylgalactosamine-κ-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow. Agric. Biol. Chem. 49 (1985) 1059–1069.
[EC 2.4.1.41 created 1972, modified 1989]
 
 


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