The Enzyme Database

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EC 2.4.1.310     
Accepted name: vancomycin aglycone glucosyltransferase
Reaction: UDP-α-D-glucose + vancomycin aglycone = UDP + devancosaminyl-vancomycin
For diagram of chloroorienticin biosynthesis, click here
Glossary: devancosaminyl-vancomycin = vancomycin pseudoaglycone
Other name(s): GtfB (ambiguous)
Systematic name: UDP-α-D-glucose:vancomycin aglycone 48-O-β-glucosyltransferase
Comments: The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Losey, H.C., Peczuh, M.W., Chen, Z., Eggert, U.S., Dong, S.D., Pelczer, I., Kahne, D. and Walsh, C.T. Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry 40 (2001) 4745–4755. [PMID: 11294642]
2.  Mulichak, A.M., Losey, H.C., Walsh, C.T. and Garavito, R.M. Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics. Structure 9 (2001) 547–557. [PMID: 11470430]
[EC 2.4.1.310 created 2013]
 
 


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