ExplorEnz: EC 2.4.1.1*

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2.4.1.189

Accepted name:

luteolin 7-O-glucuronosyltransferase

Reaction:

UDP-α-D-glucuronate + luteolin = UDP + luteolin 7-O-β-D-glucuronide

For diagram of luteolin derivatives biosynthesis, click here

Other name(s):

uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase; LGT; UDP-glucuronate:luteolin 7-O-glucuronosyltransferase

Systematic name:

UDP-α-D-glucuronate:luteolin 7-O-glucuronosyltransferase (configuration-inverting)

Comments:

The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 115490-49-8

References:

1.	Schulz, M. and Weissenböck, G. 3 specific UDP-glucuronate-flavone-glucuronosyl-transferases from primary leaves of Secale cereale. Phytochemistry 27 (1988) 1261–1267.

[EC 2.4.1.189 created 1992]

2.4.1.190

Accepted name:

luteolin-7-O-glucuronide 2′′-O-glucuronosyltransferase

Reaction:

UDP-α-D-glucuronate + luteolin 7-O-β-D-glucuronide = UDP + luteolin 7-O-[β-D-glucuronosyl-(1→2)-β-D-glucuronide]

For diagram of luteolin derivatives biosynthesis, click here

Other name(s):

uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase; LMT; UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase; UDP-glucuronate:luteolin-7-O-β-D-glucuronide 2′′-O-glucuronosyltransferase

Systematic name:

UDP-α-D-glucuronate:luteolin-7-O-β-D-glucuronide 2′′-O-glucuronosyltransferase (configuration-inverting)

Comments:

The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 115490-51-2

References:

1.	Schulz, M. and Weissenböck, G. 3 specific UDP-glucuronate-flavone-glucuronosyl-transferases from primary leaves of Secale cereale. Phytochemistry 27 (1988) 1261–1267.
2.	Anhalt, S. and Weissenböck, G. Subcellular localization of luteolin glucuronides and related enzymes in rye mesophyll. Planta 187 (1992) 83–88. [PMID: 24177970]

[EC 2.4.1.190 created 1992]

2.4.1.191

Accepted name:

luteolin-7-O-diglucuronide 4′-O-glucuronosyltransferase

Reaction:

UDP-α-D-glucuronate + luteolin 7-O-[β-D-glucuronosyl-(1→2)-β-D-glucuronide] = UDP + luteolin 7-O-[β-D-glucuronosyl-(1→2)-β-D-glucuronide]-4′-O-β-D-glucuronide

For diagram of luteolin derivatives biosynthesis, click here

Other name(s):

uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase; UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase; UDPglucuronate:luteolin 7-O-diglucuronide-4′-O-glucuronosyl-transferase; LDT; UDP-glucuronate:luteolin-7-O-β-D-diglucuronide 4′-O-glucuronosyltransferase

Systematic name:

UDP-α-D-glucuronate:luteolin-7-O-β-D-diglucuronide 4′-O-glucuronosyltransferase (configuration-inverting)

Comments:

The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 115490-50-1

References:

1.	Schulz, M. and Weissenböck, G. 3 specific UDP-glucuronate-flavone-glucuronosyl-transferases from primary leaves of Secale cereale. Phytochemistry 27 (1988) 1261–1267.

[EC 2.4.1.191 created 1992, modified 2011]

2.4.1.192

Accepted name:

nuatigenin 3β-glucosyltransferase

Reaction:

UDP-glucose + (20S,22S,25S)-22,25-epoxyfurost-5-ene-3β,26-diol = UDP + (20S,22S,25S)-22,25-epoxyfurost-5-ene-3β,26-diol 3-O-β-D-glucoside

Other name(s):

uridine diphosphoglucose-nuatigenin glucosyltransferase

Systematic name:

UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3β,26-diol 3-O-β-D-glucosyltransferase

Comments:

Some other sapogenins can act as glucosyl acceptors. Involved in the biosynthesis of plant saponins. Not identical with EC 2.4.1.173 (sterol 3β-glucosyltransferase) or EC 2.4.1.193 (sarsapogenin 3β-glucosyltransferase).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 108891-57-2

References:

1.	Kalinowska, M. and Wojciechowski, Z.A. Enzymatic-synthesis of nuatigenin 3-β-D-glucoside in oat (Avena sativa) leaves. Phytochemistry 25 (1986) 2525–2529.
2.	Kalinowska, M. and Wojciechowski, Z.A. Subcellular-localization of UDPG-nuatigenin glucosyltransferase in oat leaves. Phytochemistry 26 (1987) 353–357.

[EC 2.4.1.192 created 1992]

2.4.1.193

Accepted name:

sarsapogenin 3β-glucosyltransferase

Reaction:

UDP-glucose + (25S)-5β-spirostan-3β-ol = UDP + (25S)-5β-spirostan-3β-ol 3-O-β-D-glucoside

Other name(s):

uridine diphosphoglucose-sarsapogenin glucosyltransferase

Systematic name:

UDP-glucose:(25S)-5β-spirostan-3β-ol 3-O-β-D-glucosyltransferase

Comments:

Specific to 5β-spirostanols. Involved in the biosynthesis of plant saponins. Not identical with EC 2.4.1.173 (sterol 3β-glucosyltransferase) or EC 2.4.1.192 (nuatigenin 3β-glucosyltransferase).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 117698-14-3

References:

1.	Paczkowski, C. and Wojciechowski, Z.A. The occurrence of UDPG-dependent glucosyltransferase specific for sarsasapogenin in Asparagus officinalis. Phytochemistry 27 (1988) 2743–2747.

[EC 2.4.1.193 created 1992]

2.4.1.194

Accepted name:

4-hydroxybenzoate 4-O-β-D-glucosyltransferase

Reaction:

UDP-glucose + 4-hydroxybenzoate = UDP + 4-(β-D-glucosyloxy)benzoate

Other name(s):

uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase; UDP-glucose:4-(β-D-glucopyranosyloxy)benzoic acid glucosyltransferase; HBA glucosyltransferase; p-hydroxybenzoate glucosyltransferase; PHB glucosyltransferase; PHB-O-glucosyltransferase

Systematic name:

UDP-glucose:4-hydroxybenzoate 4-O-β-D-glucosyltransferase

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 120860-68-6

References:

1.	Katsumata, T., Shige, H. and Ejiri, S.-I. Biochemical-studies on pollen. 34. UDP glucose-4-(β-D-glucopyranosyloxy) benzoic-acid glucosyltransferase from the pollen of Pinus densiflora. Phytochemistry 28 (1989) 359–362.

[EC 2.4.1.194 created 1992]

2.4.1.195

Accepted name:

N-hydroxythioamide S-β-glucosyltransferase

Reaction:

(1) UDP-α-D-glucose + (Z)-2-phenyl-1-thioacetohydroximate = UDP + desulfoglucotropeolin
(2) UDP-α-D-glucose + an (E)-ω-(methylsulfanyl)alkyl-thiohydroximate = UDP + an aliphatic desulfoglucosinolate
(3) UDP-α-D-glucose + (E)-2-(1H-indol-3-yl)-1-thioacetohydroximate = UDP + desulfoglucobrassicin

For diagram of glucotropeolin biosynthesis, click here

Glossary:

an aliphatic desulfoglucosinolate = an ω-(methylsulfanyl)alkylhydroximate S-glucoside

Other name(s):

UGT74B1 (gene name); desulfoglucosinolate-uridine diphosphate glucosyltransferase; uridine diphosphoglucose-thiohydroximate glucosyltransferase; thiohydroximate β-D-glucosyltransferase; UDPG:thiohydroximate glucosyltransferase; thiohydroximate S-glucosyltransferase; thiohydroximate glucosyltransferase; UDP-glucose:thiohydroximate S-β-D-glucosyltransferase; UDP-glucose:N-hydroxy-2-phenylethanethioamide S-β-D-glucosyltransferase

Systematic name:

UDP-α-D-glucose:N-hydroxy-2-phenylethanethioamide S-β-D-glucosyltransferase

Comments:

The enzyme specifically glucosylates the thiohydroximate functional group. It is involved in the biosynthesis of glucosinolates in cruciferous plants, and acts on aliphatic, aromatic, and indolic substrates.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9068-14-8

References:

1.	Jain, J.C., Reed, D.W., Groot Wassink, J.W.D. and Underhill, E.W. A radioassay of enzymes catalyzing the glucosylation and sulfation steps of glucosinolate biosynthesis in Brassica species. Anal. Biochem. 178 (1989) 137–140. [DOI] [PMID: 2524977]
2.	Reed, D.W., Davin, L., Jain, J.C., Deluca, V., Nelson, L. and Underhill, E.W. Purification and properties of UDP-glucose:thiohydroximate glucosyltransferase from Brassica napus L. seedlings. Arch. Biochem. Biophys. 305 (1993) 526–532. [DOI] [PMID: 8373190]
3.	Marillia, E.F., MacPherson, J.M., Tsang, E.W., Van Audenhove, K., Keller, W.A. and GrootWassink, J.W. Molecular cloning of a Brassica napus thiohydroximate S-glucosyltransferase gene and its expression in Escherichia coli. Physiol. Plant. 113 (2001) 176–184. [PMID: 12060294]
4.	Fahey, J.W., Zalcmann, A.T. and Talalay, P. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 56 (2001) 5–51. [DOI] [PMID: 11198818]
5.	Grubb, C.D., Zipp, B.J., Ludwig-Muller, J., Masuno, M.N., Molinski, T.F. and Abel, S. Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis. Plant J. 40 (2004) 893–908. [DOI] [PMID: 15584955]

[EC 2.4.1.195 created 1992, modified 2006, modified 2018]

2.4.1.196

Accepted name:

nicotinate glucosyltransferase

Reaction:

UDP-glucose + nicotinate = UDP + N-glucosylnicotinate

Other name(s):

uridine diphosphoglucose-nicotinate N-glucosyltransferase; UDP-glucose:nicotinic acid-N-glucosyltransferase

Systematic name:

UDP-glucose:nicotinate N-glucosyltransferase

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 120858-56-2

References:

1.	Upmeier, B., Thomzik, J.E. and Barz, W. Enzymatic studies on the reversible synthesis of nicotinic acid-N-glucoside in heterotrophic parsley cell suspension cultures. Z. Naturforsch. C: Biosci. 43 (1988) 835–842.

[EC 2.4.1.196 created 1992]

2.4.1.197

Accepted name:

high-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase

Reaction:

Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked α-(1→6) to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum

Other name(s):

uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase; acetylglucosamine-oligosaccharide acetylglucosaminyltransferase; UDP-GlcNAc:oligosaccharide β-N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase

Systematic name:

UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide 4-β-N-acetylglucosaminyltransferase

Comments:

The activity of the intersecting mannose residue as acceptor is dependent on two other mannose residues attached by α-1,3 and α-1,6 links.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 123425-54-7

References:

1.	Sharkey, D.J. and Kornfeld, R. Identification of an N-acetylglucosaminyltransferase in Dictyostelium discoideum that transfers an "intersecting" N-acetylglucosamine residue to high mannose oligosaccharides. J. Biol. Chem. 264 (1989) 10411–10419. [PMID: 2525124]

[EC 2.4.1.197 created 1992]

2.4.1.198

Accepted name:

phosphatidylinositol N-acetylglucosaminyltransferase

Reaction:

UDP-N-acetyl-α-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

For diagram of glycosylphosphatidyl-myo-inositol biosynthesis, click here

Glossary:

1-phosphatidyl-1D-myo-inositol = PtdIns

Other name(s):

UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase; uridine diphosphoacetylglucosamine α1,6-acetyl-D-glucosaminyltransferase; UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-α-D-glucosaminyl)transferase

Systematic name:

UDP-N-acetyl-α-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-α-D-glucosaminyl)transferase (configuration-retaining)

Comments:

Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 144388-35-2

References:

1.	Doering, T.L., Masteron, W.J., Englund, P.T. and Hart, G.W. Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine. J. Biol. Chem. 264 (1989) 11168–11173. [PMID: 2525555]
2.	Watanabe, R., Inoue, N., Westfall, B., Taron, C.H., Orlean, P., Takeda, J. and Kinoshita, T. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H , PIG-C and GPI1. EMBO J. 17 (1998) 877–885. [DOI] [PMID: 9463366]
3.	Watanabe, R., Murakami, Y., Marmor, M.D., Inoue, N., Maeda, Y., Hino, J., Kangawa, K., Julius, M. and Kinoshita, T. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. EMBO J. 19 (2000) 4402–4411. [DOI] [PMID: 10944123]

[EC 2.4.1.198 created 1992, modified 2002]

2.4.1.199

Accepted name:

β-mannosylphosphodecaprenol—mannooligosaccharide 6-mannosyltransferase

Reaction:

β-D-mannosylphosphodecaprenol + (1→6)-α-D-mannosyloligosaccharide = decaprenol phosphate + (1→6)-α-D-mannosyl-(1→6)-α-D-mannosyl-oligosaccharide

Other name(s):

mannosylphospholipid-methylmannoside α-1,6-mannosyltransferase; β-D-mannosylphosphodecaprenol:1,6-α-D-mannosyloligosaccharide 1,6-α-D-mannosyltransferase

Systematic name:

β-D-mannosylphosphodecaprenol:(1→6)-α-D-mannosyloligosaccharide 6-α-D-mannosyltransferase

Comments:

Involved in the formation of mannooligosaccharides in the membrane of Mycobacterium smegmatis.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 125008-27-7

References:

1.	Yokoyama, K. and Ballou, C.E. Synthesis of α1→6-mannooligosaccharides in Mycobacterium smegmatis. Function of β-mannosylphosphoryldecaprenol as the mannosyl donor. J. Biol. Chem. 264 (1989) 21621–21628. [PMID: 2480954]

[EC 2.4.1.199 created 1992]