The Enzyme Database

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EC 2.1.1.76     
Accepted name: quercetin 3-O-methyltransferase
Reaction: S-adenosyl-L-methionine + 3,5,7,3′,4′-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3′,4′-tetrahydroxyflavone
For diagram of the biosynthesis of methylated quercetin derivatives, click here
Other name(s): flavonol 3-O-methyltransferase; flavonoid 3-methyltransferase
Systematic name: S-adenosyl-L-methionine:3,5,7,3′,4′-pentahydroxyflavone 3-O-methyltransferase
Comments: Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 81295-55-8
References:
1.  De Luca, V., Brunet, G., Khouri, H., Ibrahim, R. and Hrazdina, G. Flavonol 3-O-methyltransferase in plant-tissues. Z. Naturforsch. 37 (1982) 134–135.
2.  De Luca, V. and Ibrahim, R.K. Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4′-O-methyltransferases. Arch. Biochem. Biophys. 238 (1985) 596–605. [PMID: 3994393]
3.  De Luca, V. and Ibrahim, R.K. Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4′-O-methyltransferases. Arch. Biochem. Biophys. 238 (1985) 606–618. [PMID: 3994394]
4.  Ibrahim, R.K. and De Luca, V. Polymethylated flavonol synthesis is catalyzed by distinct O-methyltransferases. Naturwissenschaften 69 (1982) 41–42.
[EC 2.1.1.76 created 1984]
 
 


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