| EC |
2.1.1.43 |
| Accepted name: |
histone-lysine N-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine |
| Other name(s): |
protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase; S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase |
| Systematic name: |
S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase |
| Comments: |
One of a group of enzymes methylating proteins; see also EC 2.1.1.59, [cytochrome-c]-lysine N-methyltransferase and EC 2.1.1.60, calmodulin-lysine N-methyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 9055-08-7 |
| References: |
| 1. |
Paik, W.K. and Kim, S. Solubilization and partial purification of protein methylase 3 from calf thymus nuclei. J. Biol. Chem. 245 (1970) 6010–6015. [PMID: 5484460] |
| 2. |
Venkatesan, M. and McManus, I.R. Partial purification and characterization of a protein lysine methyltransferase from plasmodia of Physarum polycephalum. Biochemistry 18 (1979) 5365–5371. [PMID: 391266] |
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| [EC 2.1.1.43 created 1976, modified 1982, modified 1983] |
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