The Enzyme Database

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EC 2.1.1.38     
Accepted name: O-demethylpuromycin O-methyltransferase
Reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin
Other name(s): O-demethylpuromycin methyltransferase
Systematic name: S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase
Comments: Puromycin is the antibiotic derived from N6-dimethyladenosine by replacing the 3′-hydroxy group with an amino group and acylating this with 4-O-methyltyrosine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37257-04-8
References:
1.  Rao, M.M., Rebello, P.F. and Pogell, B.M. Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin. J. Biol. Chem. 244 (1969) 112–118. [PMID: 5773275]
[EC 2.1.1.38 created 1972]
 
 


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