The Enzyme Database

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Accepted name: cobalt-factor III methyltransferase
Reaction: S-adenosyl-L-methionine + cobalt-factor III + reduced acceptor = S-adenosyl-L-homocysteine + cobalt-precorrin-4 + acceptor
For diagram of anaerobic corrin biosynthesis (part 1), click here
Other name(s): CbiH60 (gene name)
Systematic name: S-adenosyl-L-methionine:cobalt-factor III 17-methyltransferase (ring contracting)
Comments: Isolated from Bacillus megaterium. The enzyme catalyses both methylation at C-17 and ring contraction. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Moore, S.J., Biedendieck, R., Lawrence, A.D., Deery, E., Howard, M.J., Rigby, S.E. and Warren, M.J. Characterization of the enzyme CbiH60 involved in anaerobic ring contraction of the cobalamin (vitamin B12) biosynthetic pathway. J. Biol. Chem. 288 (2013) 297–305. [PMID: 23155054]
[EC created 2013]

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