The Enzyme Database

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EC 2.1.1.139     
Accepted name: 3′-demethylstaurosporine O-methyltransferase
Reaction: S-adenosyl-L-methionine + 3′-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine
Other name(s): 3′-demethoxy-3′-hydroxystaurosporine O-methyltransferase; staurosporine synthase
Systematic name: S-adenosyl-L-methionine:3′-demethylstaurosporine O-methyltransferase
Comments: Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 212906-74-6
References:
1.  Weidner, S., Kittelmann, M., Goeke, K., Ghisalba, O. and Zahner, H. 3′-Demethoxy-3′-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine. J. Antibiot. (Tokyo) 51 (1998) 679–682. [PMID: 9727395]
[EC 2.1.1.139 created 2000]
 
 


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