The Enzyme Database

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Accepted name: hydrazine oxidoreductase
Reaction: hydrazine + acceptor = N2 + reduced acceptor
Other name(s): HAO (ambiguous; cf. EC hydroxylamine oxidase)
Systematic name: hydrazine:acceptor oxidoreductase
Comments: The enzyme is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria. The conversion of hydroxylamine by the enzyme from Brocadia anammoxidans results in the formation of NO and N2O [1]. Hydroxylamine is not a substrate for the enzyme from planctomycete KSU-1 [2].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9075-43-8
1.  Schalk, J., de Vries, S., Kuenen, J.G. and Jetten, M.S. Involvement of a novel hydroxylamine oxidoreductase in anaerobic ammonium oxidation. Biochemistry 39 (2000) 5405–5412. [PMID: 10820012]
2.  Jetten, M.S., Wagner, M., Fuerst, J., van Loosdrecht, M., Kuenen, G. and Strous, M. Microbiology and application of the anaerobic ammonium oxidation ('anammox') process. Curr. Opin. Biotechnol. 12 (2001) 283–288. [PMID: 11404106]
[EC created 2003, modified 2010]

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