The Enzyme Database

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EC 1.3.99.16     
Accepted name: isoquinoline 1-oxidoreductase
Reaction: isoquinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor
Systematic name: isoquinoline:acceptor 1-oxidoreductase (hydroxylating)
Comments: The enzyme from Pseudomonas diminuta is specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Electron acceptors include 1,2-benzoquinone, cytochrome c, ferricyanide, iodonitrotetrazolium chloride, nitroblue tetrazolium, Meldola blue and phenazine methosulfate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 155948-73-5
References:
1.  Lehmann, M., Tshisuaka, B., Fetzner, S., Roger, P. and Lingens, F. Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase. J. Biol. Chem. 269 (1994) 11254–11260. [PMID: 8157655]
2.  Lehmann, M., Tshisuaka, B., Fetzner, S. and Lingens, F. Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases. J. Biol. Chem. 270 (1995) 14420–14429. [DOI] [PMID: 7782304]
[EC 1.3.99.16 created 1999]
 
 


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