| EC |
1.3.1.30 |
| Accepted name: |
progesterone 5α-reductase |
| Reaction: |
5α-pregnan-3,20-dione + NADP+ = progesterone + NADPH + H+ |
| Other name(s): |
steroid 5-α-reductase; Δ4-steroid 5α-reductase (progesterone) |
| Systematic name: |
5α-pregnan-3,20-dione:NADP+ 5-oxidoreductase |
| Comments: |
Testosterone and 20α-hydroxy-4-pregn-3-one can act in place of progesterone. |
| Links to other databases: |
BRENDA, EXPASY, IUBMB, KEGG, CAS registry number: 72412-84-1 |
| References: |
| 1. |
Cheng, Y.-J. and Karavolas, H.J. Subcellular distribution and properties of progesterone (Δ4-steroid) 5α-reductase in rat medial basal hypothalamus. J. Biol. Chem. 250 (1975) 7997–8003. [PMID: 240847] |
| 2. |
Cheng, Y.-J. and Karavolas, H.J. Properties and subcellular distribution of Δ4-steroid (progesterone) 5α-reductase in rat anterior pituitary. Steroids 26 (1975) 57–71. [PMID: 1166484] |
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| [EC 1.3.1.30 created 1978] |
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