The Enzyme Database

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Accepted name: methylarsonate reductase
Reaction: methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O
For diagram of arsenate catabolism, click here
Glossary: methylarsonite = methylarsonous acid
cacodylic acid = dimethylarsinic acid
Other name(s): MMA(V) reductase
Systematic name: methylarsonate:glutathione oxidoreductase
Comments: The product, methylarsonite, is biologically methylated by EC, arsenite methyltransferase, to form cacodylic acid.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, UM-BBD, CAS registry number: 254889-62-8
1.  Zakharyan, R.A. and Aposhian, H.V. Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase. Chem. Res. Toxicol. 12 (1999) 1278–1283. [PMID: 10604879]
[EC created 2000 as EC, transferred 2001 to EC, modified 2003]

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