The Enzyme Database

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EC 1.2.1.49     
Accepted name: 2-oxoaldehyde dehydrogenase (NADP+)
Reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo carboxylate + NADPH + H+
Other name(s): α-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NADP+-linked α-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NADP+-dependent α-ketoaldehyde dehydrogenase
Systematic name: 2-oxoaldehyde:NADP+ 2-oxidoreductase
Comments: Not identical with EC 1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 83588-97-0, 97162-76-0
References:
1.  Ray, M. and Ray, S. On the interaction of nucleotides and glycolytic intermediates with NAD-linked α-ketoaldehyde dehydrogenase. J. Biol. Chem. 257 (1982) 10571–10574. [PMID: 7107626]
2.  Ray, S. and Ray, M. Purification and characterization of NAD and NADP-linked α-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate. J. Biol. Chem. 257 (1982) 10566–10570. [PMID: 7107625]
[EC 1.2.1.49 created 1986]
 
 


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