| EC |
1.14.99.9 |
| Accepted name: |
steroid 17α-monooxygenase |
| Reaction: |
a steroid + AH2 + O2 = a 17α-hydroxysteroid + A + H2O |
| Other name(s): |
steroid 17α-hydroxylase; cytochrome P-45017α; cytochrome P-450 (P-45017α,lyase); 17α-hydroxylase-C17,20 lyase |
| Systematic name: |
steroid,hydrogen-donor:oxygen oxidoreductase (17α-hydroxylating) |
| Comments: |
Requires NAD(P)H and P-450. |
| Links to other databases: |
BRENDA, EXPASY, IUBMB, KEGG, PDB, CAS registry number: 9029-67-8 |
| References: |
| 1. |
Lynn, W.S. and Brown, R.H. The conversion of progesterone to androgens by testes. J. Biol. Chem. 232 (1958) 1015–1030. [PMID: 13549484] |
| 2. |
Yoshida, K.-I., Oshima, H. and Troen, P. Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17α-hydroxylation. J. Clin. Endocrinol. Metab. 50 (1980) 895–899. [PMID: 6966286] |
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| [EC 1.14.99.9 created 1961 as EC 1.99.1.9, transferred 1965 to EC 1.14.1.7, transferred 1972 to EC 1.14.99.9] |
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