The Enzyme Database

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EC 1.14.99.45     
Accepted name: carotene ε-monooxygenase
Reaction: α-carotene + reduced acceptor + O2 = α-cryptoxanthin + acceptor + H2O
For diagram of lutein biosynthesis, click here
Other name(s): CYP97C1; LUT1
Systematic name: α-carotene:oxygen oxidoreductase (3-hydroxylating)
Comments: A heme-thiolate protein (P-450). Also acts on zeinoxanthin to give lutein.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Pogson, B., McDonald, K.A., Truong, M., Britton, G. and DellaPenna, D. Arabidopsis carotenoid mutants demonstrate that lutein is not essential for photosynthesis in higher plants. Plant Cell 8 (1996) 1627–1639. [PMID: 8837513]
2.  Tian, L., Musetti, V., Kim, J., Magallanes-Lundback, M. and DellaPenna, D. The Arabidopsis LUT1 locus encodes a member of the cytochrome P450 family that is required for carotenoid ε-ring hydroxylation activity. Proc. Natl. Acad. Sci. USA 101 (2004) 402–407. [PMID: 14709673]
[EC 1.14.99.45 created 2011]
 
 


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