The Enzyme Database

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EC 1.14.99.19     
Accepted name: plasmanylethanolamine desaturase
Reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + reduced acceptor + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O
Other name(s): alkylacylglycerophosphoethanolamine desaturase; alkylacylglycero-phosphorylethanolamine dehydrogenase; dehydrogenase, alkyl-acylglycerophosphorylethanolamine; 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase; 1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase
Systematic name: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase
Comments: Requires NADPH or NADH. May involve cytochrome b5. Requires Mg2+ and ATP.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 39391-13-4
References:
1.  Paltauf, F. and Holasek, A. Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine. J. Biol. Chem. 248 (1973) 1609–1615. [PMID: 4144394]
2.  Wykle, R.L., Blank, M.L., Malone, B. and Snyder, F. Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine. J. Biol. Chem. 247 (1972) 5442–5447. [PMID: 4403444]
[EC 1.14.99.19 created 1976]
 
 


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