The Enzyme Database

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Accepted name: aminocyclopropanecarboxylate oxidase
Reaction: 1-aminocyclopropane-1-carboxylate + ascorbate + O2 = ethylene + cyanide + dehydroascorbate + CO2 + 2 H2O
For diagram of ethylene biosynthesis, click here
Other name(s): ACC oxidase; ethylene-forming enzyme
Systematic name: 1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)
Comments: A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethylene has signalling functions such as stimulation of fruit-ripening.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 98668-53-2
1.  Zhang, Z.H., Schofield, C.J., Baldwin, J.E., Thomas, P. and John, P. Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli. Biochem. J. 307 (1995) 77–85. [PMID: 7717997]
2.  Zhang, Z.H., Barlow, J.N., Baldwin, J.E. and Schofield, C.J. Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase. Biochemistry 36 (1997) 15999–16007. [PMID: 9398335]
3.  Pirrung, M.C. Ethylene biosynthesis from 1-aminocyclopropanecarboxylic acid. Acc. Chem. Res. 32 (1999) 711–718.
4.  Charng, Y., Chou, S.J., Jiaang, W.T., Chen, S.T. and Yang, S.F. The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase. Arch. Biochem. Biophys. 385 (2001) 179–185. [PMID: 11361015]
5.  Thrower, J.S., Blalock, R. and Klinman, J.P. Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase. Biochemistry 40 (2001) 9717–9724. [PMID: 11583172]
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