The Enzyme Database

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EC 1.14.15.1     
Accepted name: camphor 5-monooxygenase
Reaction: (+)-camphor + reduced putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O
For diagram of camphor catabolism, click here
Other name(s): camphor 5-exo-methylene hydroxylase; 2-bornanone 5-exo-hydroxylase; bornanone 5-exo-hydroxylase; camphor 5-exo-hydroxylase; camphor 5-exohydroxylase; camphor hydroxylase; d-camphor monooxygenase; methylene hydroxylase; methylene monooxygenase; D-camphor-exo-hydroxylase; camphor methylene hydroxylase
Systematic name: (+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)
Comments: A heme-thiolate protein (P-450). Also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholide.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, UM-BBD, CAS registry number: 9030-82-4
References:
1.  Hedegaard, J. and Gunsalus, I.C. Mixed function oxidation. IV. An induced methylene hydroxylase in camphor oxidation. J. Biol. Chem. 240 (1965) 4038–4043. [PMID: 4378858]
2.  Tyson, C.A., Lipscomb, J.D. and Gunsalus, I.C. The role of putidaredoxin and P450cam in methylene hydroxylation. J. Biol. Chem. 247 (1972) 5777–5784. [PMID: 4341491]
[EC 1.14.15.1 created 1972, modified 1986]
 
 


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