The Enzyme Database

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EC 1.14.13.71     
Accepted name: N-methylcoclaurine 3′-monooxygenase
Reaction: (S)-N-methylcoclaurine + NADPH + H+ + O2 = (S)-3′-hydroxy-N-methylcoclaurine + NADP+ + H2O
For diagram of reticuline biosynthesis, click here
Other name(s): N-methylcoclaurine 3′-hydroxylase
Systematic name: (S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3′-hydroxylating)
Comments: A heme-thiolate protein (P-450) involved in benzylisoquinoline alkaloid synthesis in higher plants.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 202420-37-9
References:
1.  Pauli, H.H. and Kutchan, T.M. Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3′-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis. Plant J. 13 (1998) 793–801. [PMID: 9681018]
[EC 1.14.13.71 created 2001]
 
 


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