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Your query returned 1 entry. 
Printable version
| EC | 1.14.13.39 | ||||||||
| Accepted name: | nitric-oxide synthase (NADPH dependent) | ||||||||
| Reaction: | 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O (overall reaction) (1a) 2 L-arginine + 2 NADPH + 2 H+ + 2 O2 = 2 Nω-hydroxy-L-arginine + 2 NADP+ + 2 H2O (1b) 2 Nω-hydroxy-L-arginine + NADPH + H+ + 2 O2 = 2 L-citrulline + 2 nitric oxide + NADP+ + 2 H2O |
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| Other name(s): | nitric oxide synthetase; endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase; NADPH-diaphorase | ||||||||
| Systematic name: | L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) | ||||||||
| Comments: | Binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin. This eukaryotic enzyme, which is found in plants [4] and animals [1-3], consists of oxygenase and reductase domains that are linked via a regulatory calmodulin-binding domain. Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. May produce superoxide under certain conditions [3]. cf. EC 1.14.13.165, nitric-oxide synthase [NAD(P)H dependent]. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 125978-95-2 | ||||||||
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