The Enzyme Database

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EC 1.14.13.174     
Accepted name: averantin hydroxylase
Reaction: (1) (1′S)-averantin + NADPH + H+ + O2 = (1′S,5′S)-5′-hydroxyaverantin + NADP+ + H2O
(2) (1′S)-averantin + NADPH + H+ + O2 = (1′S,5′R)-5′-hydroxyaverantin + NADP+ + H2O
For diagram of aflatoxin biosynthesis (part 1), click here
Glossary: averantin = 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxyhexyl]anthracene-9,10-dione
Other name(s): AVN hydroxylase; avnA (gene name); (1′S)-averantin,NADPH:O2 oxidoreductase (5′-hydroxylating)
Systematic name: (1′S)-averantin,NADPH:oxygen oxidoreductase (5′-hydroxylating)
Comments: A heme-thiolate (P-450) monooxygenase isolated from Aspergillus parasiticus. There is no reaction with (1′R)-averantin. Involved in aflatoxin biosynthesis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Yabe, K., Matsuyama, Y., Ando, Y., Nakajima, H. and Hamasaki, T. Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin. Appl. Environ. Microbiol. 59 (1993) 2486–2492. [PMID: 8368836]
[EC 1.14.13.174 created 2013]
 
 


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