The Enzyme Database

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EC 1.14.13.173     
Accepted name: 11-oxo-β-amyrin 30-oxidase
Reaction: 11-oxo-β-amyrin + 3 O2 + 3 NADPH + 3 H+ = glycyrrhetinate + 3 NADP+ + 4 H2O (overall reaction)
(1a) 11-oxo-β-amyrin + O2 + NADPH + H+ = 30-hydroxy-11-oxo-β-amyrin + NADP+ + H2O
(1b) 30-hydroxy-11-oxo-β-amyrin + O2 + NADPH + H+ = glycyrrhetaldehyde + NADP+ + 2 H2O
(1c) glycyrrhetaldehyde + O2 + NADPH + H+ = glycyrrhetinate + NADP+ + H2O
For diagram of glycyrrhenate biosynthesis, click here
Other name(s): CYP72A; CYP72A154
Systematic name: 11-oxo-β-amyrin,NADPH:oxygen oxidoreductase (30-hydroxylating)
Comments: A heme-thiolate protein (cytochrome P-450). The enzyme is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin in the plant Glycyrrhiza uralensis (licorice). The enzyme from the plant Medicago truncatula can also hydroxylate β-amyrin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Seki, H., Sawai, S., Ohyama, K., Mizutani, M., Ohnishi, T., Sudo, H., Fukushima, E.O., Akashi, T., Aoki, T., Saito, K. and Muranaka, T. Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell 23 (2011) 4112–4123. [PMID: 22128119]
[EC 1.14.13.173 created 2013]
 
 


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