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Your query returned 11 entries. Printable version
EC | 1.14.13.17 | ||||
Transferred entry: | cholesterol 7α-monooxygenase. Now EC 1.14.14.23, cholesterol 7α-monooxygenase | ||||
EC | 1.14.13.170 | ||||
Accepted name: | pentalenolactone D synthase | ||||
Reaction: | 1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = pentalenolactone D + NADP+ + H2O | ||||
For diagram of pentalenolactone biosynthesis, click here | |||||
Glossary: | 1-deoxy-11-oxopentalenate = (1S,3aR,5aS)-1,7,7-trimethyl-2-oxo-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate pentalenolactone D = (1S,4aR,6aS,9aR)-1,8,8-trimethyl-2-oxo-1,2,4,4a,6a,7,8,9-octahydropentaleno[1,6a-c]pyran-5-carboxylate |
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Other name(s): | penE (gene name); pntE (gene name) | ||||
Systematic name: | 1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (pentalenolactone-D-forming) | ||||
Comments: | A FAD-dependent oxygenase. Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. The ketone undergoes a biological Baeyer-Villiger reaction. Part of the pathway of pentalenolactone biosynthesis. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 1.14.13.171 | ||||
Accepted name: | neopentalenolactone D synthase | ||||
Reaction: | 1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = neopentalenolactone D + NADP+ + H2O | ||||
For diagram of pentalenolactone biosynthesis, click here | |||||
Glossary: | 1-deoxy-11-oxopentalenate = (1S,3aR,5aS)-1,7,7-trimethyl-2-oxo-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate neopentalenolactone D = (1S,4aR,6aS)-1,7,7-trimethyl-3-oxo-4,4a,6a,7,8,9-hexahydro-3H-pentaleno[6a,1-c]pyran-5-carboxylate |
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Other name(s): | ptlE (gene name) | ||||
Systematic name: | 1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (neopentalenolactone-D-forming) | ||||
Comments: | A FAD-dependent oxygenase. Isolated from the bacterium Streptomyces avermitilis. The ketone undergoes a biological Baeyer-Villiger reaction. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 1.14.13.172 | ||||
Accepted name: | salicylate 5-hydroxylase | ||||
Reaction: | salicylate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O | ||||
Glossary: | 2,5-dihydroxybenzoate = gentisate | ||||
Other name(s): | nagG (gene name); nagH (gene name) | ||||
Systematic name: | salicylate,NADH:oxygen oxidoreductase (5-hydroxylating) | ||||
Comments: | This enzyme, which was characterized from the bacterium Ralstonia sp. U2, comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.7, ferredoxin—NAD(P)+ reductase), an iron-sulfur oxygenase, and ferredoxin. | ||||
Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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EC | 1.14.13.173 | ||||
Transferred entry: | 11-oxo-β-amyrin 30-oxidase. Now EC 1.14.14.115, 11-oxo-β-amyrin 30-oxidase. | ||||
EC | 1.14.13.174 | ||||
Transferred entry: | averantin hydroxylase. Now EC 1.14.14.116, averantin hydroxylase | ||||
EC | 1.14.13.175 | ||||
Transferred entry: | aflatoxin B synthase. Now EC 1.14.14.117, aflatoxin B synthase | ||||
EC | 1.14.13.176 | ||||
Transferred entry: | tryprostatin B 6-hydroxylase. Now EC 1.14.14.118, tryprostatin B 6-hydroxylase | ||||
EC | 1.14.13.177 | ||||
Transferred entry: | fumitremorgin C monooxygenase. Now EC 1.14.14.119, fumitremorgin C monooxygenase | ||||
EC | 1.14.13.178 | ||||
Accepted name: | methylxanthine N1-demethylase | ||||
Reaction: | (1) caffeine + O2 + NAD(P)H + H+ = theobromine + NAD(P)+ + H2O + formaldehyde (2) theophylline + O2 + NAD(P)H + H+ = 3-methylxanthine + NAD(P)+ + H2O + formaldehyde (3) paraxanthine + O2 + NAD(P)H + H+ = 7-methylxanthine + NAD(P)+ + H2O + formaldehyde |
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Glossary: | caffeine = 1,3,7-trimethylxanthine theobromine = 3,7-dimethylxanthine theophylline = 1,3-dimethylxanthine paraxanthine = 1,7-dimethylxanthine |
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Other name(s): | ndmA (gene name) | ||||
Systematic name: | caffeine:oxygen oxidoreductase (N1-demethylating) | ||||
Comments: | A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, methylxanthine N3-demethylase, and has a 5-fold higher activity with NADH than with NADPH [2]. Also demethylate 1-methylxantine with lower efficiency. Forms part of the degradation pathway of methylxanthines. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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EC | 1.14.13.179 | ||||
Accepted name: | methylxanthine N3-demethylase | ||||
Reaction: | (1) theobromine + O2 + NAD(P)H + H+ = 7-methylxanthine + NAD(P)+ + H2O + formaldehyde (2) 3-methylxanthine + O2 + NAD(P)H + H+ = xanthine + NAD(P)+ + H2O + formaldehyde |
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Glossary: | theobromine = 3,7-dimethylxanthine |
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Other name(s): | ndmB (gene name) | ||||
Systematic name: | theobromine:oxygen oxidoreductase (N3-demethylating) | ||||
Comments: | A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, methylxanthine N1-demethylase, and has higher activity with NADH than with NADPH [1]. Also demethylates caffeine and theophylline with lower efficiency. Forms part of the degradation pathway of methylxanthines. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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