The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 1.14.13.158     
Accepted name: amorpha-4,11-diene 12-monooxygenase
Reaction: amorpha-4,11-diene + 3 O2 + 3 NADPH + 3 H+ = artemisinate + 3 NADP+ + 4 H2O (overall reaction)
(1a) amorpha-4,11-diene + O2 + NADPH + H+ = artemisinic alcohol + NADP+ + H2O
(1b) artemisinic alcohol + O2 + NADPH + H+ = artemisinic aldehyde + NADP+ + 2 H2O
(1c) artemisinic aldehyde + O2 + NADPH + H+ = artemisinate + NADP+ + H2O
For diagram of artemisinin biosynthesis, click here
Other name(s): CYP71AV1
Systematic name: amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating)
Comments: A heme-thiolate protein (P-450). Cloned from the plant Artemisia annua (sweet wormwood). Part of the biosynthetic pathway of artemisinin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Teoh, K.H., Polichuk, D.R., Reed, D.W., Nowak, G. and Covello, P.S. Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin. FEBS Lett. 580 (2006) 1411–1416. [PMID: 16458889]
[EC 1.14.13.158 created 2012]
 
 


Data © 2001–2016 IUBMB
Web site © 2005–2016 Andrew McDonald