The Enzyme Database

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EC 1.14.13.150     
Accepted name: α-humulene 10-hydroxylase
Reaction: α-humulene + O2 + NADPH + H+ = 10-hydroxy-α-humulene + NADP+ + H2O
For diagram of zerumbone biosynthesis, click here
Other name(s): CYP71BA1
Systematic name: α-humulene,NADPH:oxygen 10-oxidoreductase
Comments: Requires cytochrome P-450. The recommended numbering of humulene gives 10-hydroxy-α-humulene as the product rather than 8-hydroxy-α-humulene as used by the reference. See Section F: Natural Product Nomenclature.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Yu, F., Okamoto, S., Harada, H., Yamasaki, K., Misawa, N. and Utsumi, R. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. Cell. Mol. Life Sci. 68 (2011) 1033–1040. [PMID: 20730551]
[EC 1.14.13.150 created 2012]
 
 


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