The Enzyme Database

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Accepted name: angelicin synthase
Reaction: (+)-columbianetin + NADPH + H+ + O2 = angelicin + NADP+ + acetone + 2 H2O
For diagram of psoralen biosynthesis, click here
Other name(s): CYP71AJ4 (gene name)
Systematic name: (+)-columbianetin,NADPH:oxygen oxidoreductase
Comments: This P-450 monooxygenase enzyme is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3′.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Larbat, R., Hehn, A., Hans, J., Schneider, S., Jugde, H., Schneider, B., Matern, U. and Bourgaud, F. Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis. J. Biol. Chem. 284 (2009) 4776–4785. [PMID: 19098286]
[EC created 2010]

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