The Enzyme Database

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Accepted name: trans-cinnamate 4-monooxygenase
Reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O
For diagram of chalcone and stilbene biosynthesis, click here
Other name(s): cinnamic acid 4-hydroxylase; oxygenase, cinnamate 4-mono-; CA4H ; cytochrome P450 cinnamate 4-hydroxylase; cinnamate 4-hydroxylase; cinnamate 4-monooxygenase; cinnamate hydroxylase; cinnamic 4-hydroxylase; cinnamic acid 4-monooxygenase; cinnamic acid p-hydroxylase; hydroxylase, cinnamate 4-; t-cinnamic acid hydroxylase; trans-cinnamate 4-hydroxylase; trans-cinnamic acid 4-hydroxylase
Systematic name: trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)
Comments: NADH also acts, more slowly. Involves a heme-thiolate protein (P-450).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9077-75-2
1.  Potts, J.R.M., Weklych, R. and Conn, E.E. The 4-hydroxylation of cinnamic acid by sorghum microsomes and the requirement for cytochrome P-450. J. Biol. Chem. 249 (1974) 5019–5026. [PMID: 4153152]
2.  Russell, D.W. and Conn, E.E. The cinnamic acid 4-hydroxylase of pea seedlings. Arch. Biochem. Biophys. 122 (1967) 256–268. [DOI] [PMID: 4383827]
[EC created 1976]

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