The Enzyme Database

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EC 1.14.12.5     
Accepted name: 5-pyridoxate dioxygenase
Reaction: 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+
Other name(s): 5-pyridoxate oxidase; 5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)
Systematic name: 5-pyridoxate,NADPH:oxygen oxidoreductase (ring-opening)
Comments: A flavoprotein.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, UM-BBD, CAS registry number: 37256-70-5
References:
1.  Sparrow, L.G., Ho, P.P.K., Sundaram, T.K., Zach, D., Nyns, E.J. and Snell, E.E. The bacterial oxidation of vitamin B6. VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypyridine ring. J. Biol. Chem. 244 (1969) 2590–2600. [PMID: 4306031]
[EC 1.14.12.5 created 1972]
 
 


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