The Enzyme Database

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EC 1.13.12.21     
Accepted name: tetracenomycin-F1 monooxygenase
Reaction: tetracenomycin F1 + O2 = tetracenomycin D3 + H2O
For diagram of tetracenomycin biosynthesis, click here
Glossary: tetracenomycin D3 = 3,8,10,12-tetrahydroxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate = 6,11-dihydro-3,8,10,12-tetrahydroxy-1-methyl-6,11-dioxonaphthacene-2-carboxylate
tetracenomycin F1 = 3,8,10,12-tetrahydroxy-1-methyl-11-oxo-6,11-dihydro-2-tetracenecarboxylate = 6,11-dihydro-3,8,10,12-tetrahydroxy-1-methyl-11-oxonaphthacene-2-carboxylate
Other name(s): tcmH (gene name)
Systematic name: tetracenomycin-F1:oxygen C5-monooxygenase
Comments: The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Shen, B. and Hutchinson, C.R. Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. Biochemistry 32 (1993) 6656–6663. [PMID: 8329392]
[EC 1.13.12.21 created 2013]
 
 


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