EC |
1.13.11.27 |
Accepted name: |
4-hydroxyphenylpyruvate dioxygenase |
Reaction: |
4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 |
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For diagram of 4-hydroxyphenylpyruvate metabolites, click here |
Other name(s): |
p-hydroxyphenylpyruvic hydroxylase; p-hydroxyphenylpyruvate hydroxylase; p-hydroxyphenylpyruvate oxidase; p-hydroxyphenylpyruvic oxidase; p-hydroxyphenylpyruvate dioxygenase; p-hydroxyphenylpyruvic acid hydroxylase; 4-hydroxyphenylpyruvic acid dioxygenase |
Systematic name: |
4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) |
Comments: |
The Pseudomonas enzyme contains one Fe3+ per mole of enzyme; the enzymes from other sources may contain essential iron or copper. |
Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9029-72-5 |
References: |
1. |
Lindstedt, S. and Rundgren, M. Blue color, metal content, and substrate binding in 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P. J. 874. J. Biol. Chem. 257 (1982) 11922–11931. [PMID: 7118918] |
2. |
Roche, P.A., Moorehead, T.J. and Hamilton, G.A. Purification and properties of hog liver 4-hydroxyphenylpyruvate dioxygenase. Arch. Biochem. Biophys. 216 (1982) 62–73. [DOI] [PMID: 7103516] |
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[EC 1.13.11.27 created 1961 as EC 1.99.1.14, transferred 1965 to EC 1.14.2.2, transferred 1972 to EC 1.13.11.27] |
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