ExplorEnz: EC 1.11.1.18

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1.11.1.18

Accepted name:

bromide peroxidase

Reaction:

RH + HBr + H₂O₂ = RBr + 2 H₂O

Other name(s):

bromoperoxidase; haloperoxidase (ambiguous); eosinophil peroxidase

Systematic name:

bromide:hydrogen-peroxide oxidoreductase

Comments:

Bromoperoxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate. They catalyse the bromination of a range of organic molecules such as sesquiterpenes, forming stable C-Br bonds. Bromoperoxidases also oxidize iodides.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	De Boer, E., Tromp, M.G.M., Plat, H., Krenn, G.E. and Wever, R Vanadium(v) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina. Biochim. Biophys. Acta 872 (1986) 104–115.
2.	Tromp, M.G., Olafsson, G., Krenn, B.E. and Wever, R. Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum. Biochim. Biophys. Acta 1040 (1990) 192–198. [DOI] [PMID: 2400770]
3.	Isupov, M.N., Dalby, A.R., Brindley, A.A., Izumi, Y., Tanabe, T., Murshudov, G.N. and Littlechild, J.A. Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis. J. Mol. Biol. 299 (2000) 1035–1049. [DOI] [PMID: 10843856]
4.	Carter-Franklin, J.N. and Butler, A. Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products. J. Am. Chem. Soc. 126 (2004) 15060–15066. [DOI] [PMID: 15548002]
5.	Ohshiro, T., Littlechild, J., Garcia-Rodriguez, E., Isupov, M.N., Iida, Y., Kobayashi, T. and Izumi, Y. Modification of halogen specificity of a vanadium-dependent bromoperoxidase. Protein Sci. 13 (2004) 1566–1571. [DOI] [PMID: 15133166]

[EC 1.11.1.18 created 2010]