| EC |
1.1.99.38 |
| Accepted name: |
2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent) |
| Reaction: |
2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5′-deoxyadenosine + L-methionine |
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For diagram of paromamine biosynthesis, click here |
| Other name(s): |
btrN (gene name); 2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) |
| Systematic name: |
2-deoxy-scyllo-inosamine:S-adenosyl-L-methionine 1-oxidoreductase |
| Comments: |
Involved in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family. The enzyme from Bacillus circulans was shown to be a radical S-adenosyl-L-methionine (SAM) enzyme. cf. EC 1.1.1.329, 2-deoxy-scyllo-inosamine dehydrogenase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Yokoyama, K., Numakura, M., Kudo, F., Ohmori, D. and Eguchi, T. Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin. J. Am. Chem. Soc. 129 (2007) 15147–15155. [DOI] [PMID: 18001019] |
| 2. |
Yokoyama, K., Ohmori, D., Kudo, F. and Eguchi, T. Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy. Biochemistry 47 (2008) 8950–8960. [DOI] [PMID: 18672902] |
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| [EC 1.1.99.38 created 2012, modified 2013] |
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