ExplorEnz: EC 1.1.1.255

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1.1.1.255

Accepted name:

mannitol dehydrogenase

Reaction:

D-mannitol + NAD⁺ = D-mannose + NADH + H⁺

Other name(s):

MTD; NAD-dependent mannitol dehydrogenase

Systematic name:

mannitol:NAD⁺ 1-oxidoreductase

Comments:

The enzyme from Apium graveolens (celery) oxidizes alditols with a minimum requirement of 2R chirality at the carbon adjacent to the primary carbon undergoing the oxidation. The enzyme is specific for NAD⁺ and does not use NADP⁺.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 144941-29-7

References:

1.	Stoop, J.M.H. and Pharr, D.M. Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots. Arch. Biochem. Biophys. 298 (1992) 612–619. [DOI] [PMID: 1416989]
2.	Stoop, J.M.H., Williamson, J.D., Conkling, M.A. and Pharr, D.M. Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures. Plant Physiol. (1995) 108 (1995) 1219–1225. [PMID: 7630943]
3.	Williamson, J.D., Stoop, J.M.H., Massel, M.O., Conkling, M.A. and Pharr, D.M. Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3. Proc. Natl. Acad. Sci. USA 92 (1995) 7148–7152. [DOI] [PMID: 7638158]
4.	Stoop, J.M.H., Chilton, W.S. and Pharr, D.M. Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery. Phytochemistry 43 (1996) 1145–1150.

[EC 1.1.1.255 created 2000]