The Enzyme Database

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Accepted name: 7α-hydroxysteroid dehydrogenase
Reaction: cholate + NAD+ = 3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate + NADH + H+
Glossary: cholate = 3α,7α,12α-trihydroxy-5β-cholan-24-oate
Other name(s): 7α-hydroxy steroid dehydrogenase; 7α-HSDH
Systematic name: 7α-hydroxysteroid:NAD+ 7-oxidoreductase
Comments: Catalyses the oxidation of the 7α-hydroxy group of bile acids and alcohols both in their free and conjugated forms. The Bacteroides fragilis and Clostridium enzymes can also utilize NADP+.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 39361-64-3
1.  Haslewood, E.S. and Haslewood, G.A.D. The specificity of a 7α-hydroxy steroid dehydrogenase from Escherichia coli. Biochem. J. 157 (1976) 207–210. [PMID: 786279]
2.  Macdonald, I.A. and Roach, P.D. Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum. Biochim. Biophys. Acta 665 (1981) 262–269. [PMID: 6945134]
3.  Macdonald, I.A., Williams, C.N. and Mahony, D.E. 7α-Hydroxysteroid dehydrogenase from Escherichia coli B: preliminary studies. Biochim. Biophys. Acta 309 (1973) 243–253. [PMID: 4581498]
4.  Macdonald, I.A., Williams, C.N., Mahony, D.E. and Christie, W.M. NAD- and NADP-dependent 7α-hydroxysteroid dehydrogenases from Bacteroides fragilis. Biochim. Biophys. Acta 384 (1975) 12–24. [PMID: 236764]
[EC created 1976, modified 1980]

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