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Your query returned 2 entries. Printable version
EC | 1.14.20.14 | ||||||
Accepted name: | hapalindole-type alkaloid chlorinase | ||||||
Reaction: | (1) hapalindole U + 2-oxoglutarate + O2 + chloride = hapalindole G + succinate + CO2 + H2O (2)12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride = 12-epi-fischerindole G + succinate + CO2 + H2O |
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For diagram of hapalindole/fischerindole biosynthesis, click here | |||||||
Glossary: | 12-epi-fischerindole U = (6aS,9S,10R,10aS)-9-ethenyl-10-isocyano-6,6,9-trimethyl-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole 12-epi-fischerindole G = (6aR,8R,9S,10R,10aS)-8-chloro-9-ethenyl-10-isocyano-6,6,9-trimethyl-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole |
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Other name(s): | ambO5 (gene name); welO5 (gene name) | ||||||
Systematic name: | 12-epi-fischerindole U,2-oxoglutarate:oxygen oxidoreductase (13-halogenating) | ||||||
Comments: | The enzyme, characterized from hapalindole-type alkaloids-producing cyanobacteria, is a specialized iron(II)/2-oxoglutarate-dependent oxygenase that catalyses the chlorination of its substrates in a reaction that requires oxygen, chloride ions, iron(II) and 2-oxoglutarate. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 5.5.1.33 | ||||||
Accepted name: | 12-epi-fischerindole U synthase | ||||||
Reaction: | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-fischerindole U | ||||||
For diagram of Hapalindole/Fischerindole biosynthesis, click here | |||||||
Glossary: | 12-epi-fischerindole U = (6aS,9S,10R,10aS)-9-ethenyl-10-isocyano-6,6,9-trimethyl-5H,6aH,7H,8H,10H,10aH-indeno[2,1-b]indole | ||||||
Other name(s): | fisC (gene name); fimC5 (gene name) | ||||||
Systematic name: | 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (12-epi-fischerindole U-forming) | ||||||
Comments: | The enzyme, characterized from multiple species of the cyanobacterial genus Fischerella, participates in the biosynthesis of the terpenoid indole alkaloids 12-epi-fischerindoles. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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