The Enzyme Database

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EC 7.4.2.12     
Accepted name: ABC-type cystine transporter
Reaction: (1) ATP + H2O + L-cystine-[cystine-binding protein][side 1] = ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1]
(2) ATP + H2O + D-cystine-[cystine-binding protein][side 1] = ADP + phosphate + D-cystine[side 2] + [cystine-binding protein][side 1]
Other name(s): cystine transporting ATPase; cystine ABC transporter
Systematic name: ATP phosphohydrolase (ABC-type, cystine-importing)
Comments: ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Berger, E.A. and Heppel, L.A. A binding protein involved in the transport of cystine and diaminopimelic acid in Escherichia coli. J. Biol. Chem. 247 (1972) 7684–7694. [PMID: 4564569]
2.  Chonoles Imlay, K.R., Korshunov, S. and Imlay, J.A. Physiological roles and adverse effects of the two cystine importers of Escherichia coli. J. Bacteriol. 197 (2015) 3629–3644. [PMID: 26350134]
[EC 7.4.2.12 created 2019]
 
 


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