The Enzyme Database

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Accepted name: ABC-type methionine transporter
Reaction: (1) ATP + H2O + L-methionine-[methionine-binding protein][side 1] = ADP + phosphate + L-methionine[side 2] + [methionine-binding protein][side 1]
(2) ATP + H2O + D-methionine-[methionine-binding protein][side 1] = ADP + phosphate + D-methionine[side 2] + [methionine-binding protein][side 1]
Other name(s): methionine transporting ATPase; methionine ABC transporter; metNIQ (gene names)
Systematic name: ATP phosphohydrolase (ABC-type, methionine-importing)
Comments: ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and functions to import methionine. The enzyme from Escherichia coli K-12 mediates the high affinity transport of both L- and D-methionine, as well as methionine-S-oxide and N-acetyl-DL-methionine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Merlin, C., Gardiner, G., Durand, S. and Masters, M. The Escherichia coli metD locus encodes an ABC transporter which includes Abc (MetN), YaeE (MetI), and YaeC (MetQ). J. Bacteriol. 184 (2002) 5513–5517. [PMID: 12218041]
2.  Zhang, Z., Feige, J.N., Chang, A.B., Anderson, I.J., Brodianski, V.M., Vitreschak, A.G., Gelfand, M.S. and Saier, M.H., Jr. A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily. Arch. Microbiol. 180 (2003) 88–100. [PMID: 12819857]
3.  Moussatova, A., Kandt, C., O'Mara, M.L. and Tieleman, D.P. ATP-binding cassette transporters in Escherichia coli. Biochim. Biophys. Acta 1778 (2008) 1757–1771. [PMID: 18634750]
[EC created 2019]

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