The Enzyme Database

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EC 7.2.2.16     
Accepted name: ABC-type ferric hydroxamate transporter
Reaction: ATP + H2O + Fe3+-hydroxamate complex-[hydroxamate-binding protein][side 1] = ADP + phosphate + Fe3+-hydroxamate complex[side 2] + [hydroxamate-binding protein][side 1]
Other name(s): iron(III) hydroxamate transporting ATPase; iron(III) hydroxamate ABC transporter; fhuCDB (gene names)
Systematic name: ATP phosphohydrolase [ABC-type, iron(III) hydroxamate-importing]
Comments: An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of Fe3+-complexed hydroxamate siderophores such as coprogen, ferrichrome and the ferric hydroxamate antibiotic, albomycin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Koster, W. Iron(III) hydroxamate transport across the cytoplasmic membrane of Escherichia coli. Biol. Met. 4 (1991) 23–32. [PMID: 1830209]
2.  Speziali, C.D., Dale, S.E., Henderson, J.A., Vines, E.D. and Heinrichs, D.E. Requirement of Staphylococcus aureus ATP-binding cassette-ATPase FhuC for iron-restricted growth and evidence that it functions with more than one iron transporter. J. Bacteriol. 188 (2006) 2048–2055. [PMID: 16513734]
[EC 7.2.2.16 created 2000 as EC 3.6.3.34, part transferred 2018 to EC 7.2.2.16]
 
 


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