ExplorEnz: EC 7.2.2.13

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7.2.2.13

Accepted name:

Na⁺/K⁺-exchanging ATPase

Reaction:

ATP + H₂O + 3 Na⁺_{[side 1]} + 2 K⁺_{[side 2]} = ADP + phosphate + 3 Na⁺_{[side 2]} + 2 K⁺_{[side 1]}

Other name(s):

(Na⁺ + K⁺)-activated ATPase; Na,K-activated ATPase; Na,K-pump; Na⁺,K⁺-ATPase; sodium/potassium-transporting ATPase

Systematic name:

ATP phosphohydrolase (P-type, Na⁺/K⁺-exchanging)

Comments:

A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na⁺ and influx of two K⁺ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Skou, J.C. The influence of some cations on an adenosinetriphosphatase from peripheral nerve. Biochim. Biophys. Acta 23 (1957) 394–401. [DOI] [PMID: 13412736]
2.	Post, R.L., Sen, A.K. and Rosenthal, A.S. A phosphorylated intermediate in adenosine triphosphate-dependent sodium and potassium transport across kidney membrane. J. Biol. Chem. 240 (1965) 1437–1445. [DOI] [PMID: 14284759]
3.	Skou, J.C. The energy-coupled exchange of Na⁺ for K⁺ across the cell membrane. The Na⁺,K⁺ pump. FEBS Lett. 268 (1990) 314–324. [DOI] [PMID: 2166689]
4.	Castillo, J.P., Rui, H., Basilio, D., Das, A., Roux, B., Latorre, R., Bezanilla, F. and Holmgren, M. Mechanism of potassium ion uptake by the Na⁺/K⁺-ATPase. Nat. Commun. 6:7622 (2015). [DOI] [PMID: 26205423]
5.	Guo, Y., Zhang, Y., Yan, R., Huang, B., Ye, F., Wu, L., Chi, X., Shi, Y. and Zhou, Q. Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states. Nat. Commun. 13:3957 (2022). [DOI] [PMID: 35803952]

[EC 7.2.2.13 created 1984 EC 3.6.1.37, transferred 2000 to EC 3.6.3.9, modified 2001, transferred 2018 to EC 7.2.2.13]