| EC |
7.1.1.11 |
| Accepted name: |
ferredoxin—NAD+ oxidoreductase (H+-transporting) |
| Reaction: |
2 reduced ferredoxin [iron-sulfur] cluster + NAD+ + H+ + 2 H+[side 1] = 2 oxidized ferredoxin [iron-sulfur] cluster + NADH + 2 H+[side 2] |
| Other name(s): |
Rnf complex (ambiguous); H+-translocating ferredoxin:NAD+ oxidoreductase |
| Systematic name: |
ferredoxin:NAD+ oxidoreductase (H+-transporting) |
| Comments: |
This iron-sulfur and flavin-containing electron transport complex, isolated from some anaerobic bacteria, couples the energy from reduction of NAD+ by ferredoxin to pumping protons out of the cell, generating a proton motive force across the cytoplasmic membrane. Most similar complexes pump sodium ions rather than protons [cf. EC 7.2.1.2, ferredoxin—NAD+ oxidoreductase (Na+-transporting)]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Tremblay, P.L., Zhang, T., Dar, S.A., Leang, C. and Lovley, D.R. The Rnf complex of Clostridium ljungdahlii is a proton-translocating ferredoxin:NAD+ oxidoreductase essential for autotrophic growth. mBio 4 (2012) e00406. [DOI] [PMID: 23269825] |
| 2. |
Wang, L., Bradstock, P., Li, C., McInerney, M.J. and Krumholz, L.R. The role of Rnf in ion gradient formation in Desulfovibrio alaskensis. PeerJ 4:e1919 (2016). [DOI] [PMID: 27114876] |
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| [EC 7.1.1.11 created 2021] |
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