The Enzyme Database

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Accepted name: pyruvate carboxylase
Reaction: ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate
Other name(s): pyruvic carboxylase
Systematic name: pyruvate:carbon-dioxide ligase (ADP-forming)
Comments: A biotinyl-protein containing manganese (animal tissues) or zinc (yeast). The animal enzyme requires acetyl-CoA.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9014-19-1
1.  McClure, W.R., Lardy, H.A. and Kneifel, H.P. Rat liver pyruvate carboxylase. I. Preparation, properties, and cation specificity. J. Biol. Chem. 246 (1971) 3569–3578. [PMID: 5578910]
2.  Scrutton, M.C., Young, M.R. and Utter, M.F. Pyruvate carboxylase from baker's yeast. The presence of bound zinc. J. Biol. Chem. 245 (1970) 6220–6227. [PMID: 5484476]
3.  Seubert, W. and Remberger, U. Renigung und Wirkungsweise der Pyruvatcarboxylase aus Pseudomonas citronellolis. Biochem. Z. 334 (1961) 401–414. [PMID: 13750403]
4.  Utter, M.F. and Keech, D.B. Pyruvate carboxylase. I. Nature of the reaction. J. Biol. Chem. 238 (1963) 2603–2608. [PMID: 14063279]
[EC created 1961]

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