| EC |
5.6.2.2 |
| Accepted name: |
DNA topoisomerase (ATP-hydrolysing) |
| Reaction: |
ATP-dependent breakage, passage and rejoining of double-stranded DNA |
| Other name(s): |
type II DNA topoisomerase; DNA-gyrase; deoxyribonucleate topoisomerase; deoxyribonucleic topoisomerase; topoisomerase; DNA topoisomerase II |
| Systematic name: |
DNA topoisomerase (ATP-hydrolysing) |
| Comments: |
The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.6.2.1 DNA topoisomerase). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 142805-56-9 |
| References: |
| 1. |
Gellert, M. DNA topoisomerases. Annu. Rev. Biochem. 50 (1981) 879–910. [DOI] [PMID: 6267993] |
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| [EC 5.6.2.2 created 1984 as 5.99.1.3, transferred 2019 to EC 5.6.2.2] |
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